• O Cosmedics O-Biome Hydrating & Setting Spray 50ml postbiotic facial mist for hydration, microbiome balance and skin resilience.
  • O Cosmedics O-Biome Hydrating & Setting Spray 50ml lightweight hydrating mist with OXY 229 microbiome support.
  • O Cosmedics O-Biome Hydrating & Setting Spray for instant hydration, microbiome balance and stressed or dehydrated skin.
  • O Cosmedics O-Biome Hydrating & Setting Spray with OXY 229, Sodium Hyaluronate and Aloe Vera for hydration and microbiome support.
  • O Cosmedics O-Biome Hydrating & Setting Spray with postbiotic OXY 229 technology for microbiome balance, clarity and resilience.
  • O Cosmedics O-Biome Hydrating & Setting Spray 50ml ultra-fine facial mist for lightweight hydration and makeup setting.
  • O Cosmedics O-Biome Hydrating & Setting Spray 50ml postbiotic face mist for refreshing dehydrated skin throughout the day.
  • O Cosmedics O-Biome Hydrating & Setting Spray 50ml with fine mist applicator for postbiotic hydration and easy reapplication.
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O Cosmedics

O Cosmedics O-Biome Hydrating & Setting Spray 50ml

O Cosmedics O-Biome Hydrating & Setting Spray 50ml

$65.00 AUD
$65.00 AUD
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O Cosmedics O-Biome Hydrating & Setting Spray is a postbiotic facial mist that delivers lightweight hydration while supporting a balanced skin microbiome, improved resilience and clearer-looking skin. Designed for far more than a quick refresh, it can be used throughout your skincare routine, over makeup or whenever dehydrated, dull or stressed skin needs additional moisture.

Powered by OXY 229 Microbiome, the formula helps support the skin's natural microbial ecosystem while Betaine, Sodium Hyaluronate and Aloe Vera replenish moisture and help soothe dehydration-related discomfort. Liftonin Xpress® adds a skin-smoothing and firming benefit, giving this lightweight mist a broader role than hydration alone.

The ultra-fine spray leaves skin feeling fresh and comfortable without heaviness or residue. Suitable across skin types, it is particularly useful for dehydrated, compromised or lacklustre skin, as well as oily and congestion-prone complexions that still need effective hydration. 

Product Size: 50ml

SKIN DEEP MEDISPA EXPERT VERDICT
Our rating: 4.8/5
O Cosmedics O-Biome Hydrating & Setting Spray is one I recommend when someone wants the convenience of a facial mist but I still want that step to contribute something meaningful to their skin. I particularly like it for oily or congestion-prone skin that is also dehydrated, because adding more moisture doesn't necessarily mean adding a heavier cream, and OXY 229 gives us the additional benefit of supporting the skin's microbiome and overall balance. I also reach for it when skin is looking dull, feeling depleted or regularly exposed to air conditioning, heating or travel. For me, its strength is its versatility: it can sit within a corrective routine without competing with the products doing the heavier work.

BEST FOR
Dehydration • Oily & Congestion-Prone Skin • Dullness • Microbiome Support

I wouldn't rely on O Cosmedics O-Biome Hydrating & Setting Spray alone when dehydration is significant or persistent. In that situation, I generally use O Cosmedics 4D Hyaluronic Serum as the dedicated corrective hydration step and choose an appropriate moisturiser to help retain that moisture. The spray then becomes the flexible supporting product that can be used around the rest of the routine.

Reviewed by: Diana / Founder & Head of Clinical Therapies, Skin Deep Medispa, Armadale

🔥 OUR HOT TIP
If your skin becomes shiny but still feels tight or dehydrated during the day, don't automatically reach for a richer moisturiser. I like O Cosmedics O-Biome Hydrating & Setting Spray in this situation because you can add lightweight hydration without introducing another heavy layer, making it particularly useful for combination, oily and congestion-prone skin.

Not sure if it’s right for your skin? Ask A Skin Deep Medispa Therapist

What We Love

✓ Hydrating and soothing actives
✓ Postbiotic microbiome support
✓ Water-light hydration
✓ OXY 229 Microbiome supports clearer-looking skin while helping address imbalance associated with excess sebum and visible redness.
✓ Genuinely multi-purpose for use within your skincare routine, over makeup or whenever skin needs refreshing.

Key Ingredients

✓ OXY 229 Microbiome - A postbiotic complex that supports a balanced skin microbiome, helping promote clearer-looking skin, improved resilience and a healthier skin environment.
✓ Betaine - Helps regulate water balance within the skin to support hydration, comfort and suppleness without adding heaviness.
✓ Sodium Hyaluronate - A form of Hyaluronic Acid that binds water within the skin, helping improve moisture retention, plumpness and the appearance of dehydration lines.
✓ Aloe Vera - Provides cooling, hydrating and soothing support for dehydrated, irritated or visibly stressed skin.
✓ Liftonin Xpress® - Provides an immediate surface-tightening effect to help skin appear smoother, firmer and more refined.

Ingredients: Aqua, Betaine, Aloe Barbadensis Leaf Extract, Saccharomyces Lysate, Valine, Threonine, Glutamic Acid, Glycine, Disodium Succinate, Urea, Sodium Hyaluronate, Allantoin, Pullulan, Sodium PCA, Glucose, Maltose, Fructose, Sodium Lactate, Trehalose, Porphyridium Cruentum Extract, Citric Acid, Pentylene Glycol, Glycerin, Sodium Chloride, Sorbic Acid, Hydroxypropyl Methylcellulose, Polysorbate 20, Fragrance (Parfum), Salycylic Acid, Benzyl Alcohol, Phenoxyethanol, Ethylhexylglycerin, Sodium Hydroxide.

Free from parabens, sulfates, petrochemicals and mineral oils, with no artificial colours, harsh preservatives or harsh synthetic fragrances. Vegan-friendly, gluten-free and cruelty-free.

How To Use

Mist O Cosmedics O-Biome Hydrating & Setting Spray over the face morning and evening after cleansing, or after applying your O Cosmedics corrective serums and/or moisturiser.

Use over makeup as a hydrating setting spray, or reapply throughout the day whenever skin feels tight, warm or dehydrated.

Close the eyes when misting over the face and allow the fine spray to settle naturally onto the skin.

Pair It With

O Cosmedics 4D Hyaluronic Serum

O Cosmedics B12 Smart Serum

O Cosmedics Rebalancing Cream

FAQs

What is O Cosmedics O-Biome Hydrating & Setting Spray used for?
We use O Cosmedics O-Biome Hydrating & Setting Spray when skin needs lightweight hydration alongside microbiome support. It is particularly useful for dehydration, dullness and stressed skin, as well as oily or congestion-prone skin that needs moisture without a heavy finish. Its multi-use format also means it can sit within your skincare routine or be reapplied later in the day.

What is the difference between O Cosmedics O-Biome Hydrating & Setting Spray and 4D Hyaluronic Serum?
We consider them complementary rather than interchangeable. O Cosmedics 4D Hyaluronic Serum is our more targeted choice when dehydration itself needs correcting, whereas O Cosmedics O-Biome Hydrating & Setting Spray provides lighter, flexible hydration with additional postbiotic microbiome support. For persistently dehydrated skin, we may use both within the same routine.

Is O Cosmedics O-Biome Hydrating & Setting Spray suitable for oily or congestion-prone skin?
Yes. Oily skin can still be dehydrated, and the water-light formula allows us to add moisture without relying on a richer product. OXY 229 also supports microbiome balance and helps regulate excess sebum, making the formula particularly relevant to congested complexions.

Is O Cosmedics O-Biome Hydrating & Setting Spray suitable for sensitive skin?
O Cosmedics O-Biome Hydrating & Setting Spray may suit dehydrated or stressed skin because it contains hydrating and soothing ingredients including Betaine, Aloe Vera and Sodium Hyaluronate. The current formula does contain fragrance, however, so for highly reactive or fragrance-sensitive skin we would assess suitability individually rather than automatically recommending it.

Can O Cosmedics O-Biome Hydrating & Setting Spray be used over makeup?
Yes. The ultra-fine mist can be used over makeup as a hydrating setting spray and then reapplied when your skin needs refreshing. We recommend a light, even mist rather than saturating the face.

Does O Cosmedics O-Biome Hydrating & Setting Spray replace moisturiser?
Not usually. We see it as a supporting hydration step rather than the product responsible for the entire moisturising function of a routine. Most skins will still benefit from an appropriate moisturiser to provide the level of hydration, lipids or barrier support they individually need.

Can O Cosmedics O-Biome Hydrating & Setting Spray be used after professional skin treatments?
It can be appropriate after some professional treatments. We recommend following the aftercare instructions provided by your treating therapist, as the products suitable immediately afterwards depend on the procedure performed and the condition of your skin.

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★★★★★

“My skin gets oily throughout the day but somehow still feels dehydrated. This gives me enough of a hydration boost without making me look shinier, and the mist is really fine.”

Eve, Toorak VIC

★★★★★

“I originally bought this to use over makeup but now I use it after cleansing as well. It feels fresh and light, and my foundation still looks good when I mist it in the afternoon.”

Jayde, Hobart TAS

★★★★★

“I travel regularly for work and this has become one of the products I always pack. My skin usually feels awful after flying and this is so easy to use without having to redo my whole skincare routine.”

Nicole, Brisbane QLD